You can use cryptbase with django ORM or with SQLAlchemy.
To use with SQLAlchemy:
from cryptbase import EncryptedText sensitive = Column(EncryptedText(key=DB_KEY))
To use with django:
from cryptbase import EncryptedTextField sensitive = EncryptedTextField(key=DB_KEY)
DB_KEY is 32 bytes encryption key as hex encoded string. Fields behave as TEXT fields, data are transparently encrypted when storing into the database and decrypted on retrieval.